This publication highlights recent advances in adapting denitrifying bioreactors developed in the Midwest to the Mid-Atlantic region. Denitrifying bioreactors are edge-of-field management practices that harness the activity of soil bacteria to remove excess nitrogen from drainage waters. Agricultural drainage is a significant source of nutrients to the Chesapeake Bay and important to manage. Although challenges remain with respect to adapting designs to treat ditch drainage, denitrifying bioreactors hold promise to yield water quality improvements in the Chesapeake Bay watershed.